Safety evaluation studies in vitro and in vivo are conducted on a variety of biomaterials, medical devices and related products to identify the presence of toxins or any potentially harmful effects of the product.

Primary test categories used to determine biological effect include:

• Cytotoxicity
• Sensitization
• Irritation/Intracutaneous
• Acute Systemic Toxicity
• Subchronic Toxicity
• Genotoxicity
• Implantation
• Hemocompatibility
• Chronic Toxicity
• Carcinogenicity
• Reproductive/Developmental
• Biodegradation